I'm still a nube learning this game (about 2 weeks), but I've found some handy hotkeys that new ones may not be aware of:
Quickslots: -/+: switch between your 2 different quickslots (maybe they are called “Skill bars). "shift" + [1~5]: Switch to that particular quickslot. “P” turns the 1 quickslot on/off; “+” and “-” on keypad turns quickslot 2 on/off.
Auto target party members: F1~F7: (since parties are limited to a max of 7 members)
When you are by yourself, F1 auto selects your character. When in a party, the F-keys select the member of the party that is listed at that particular spot (i.e. F3 would select the third person listed on the party list)
Select nearest enemy: "~" or "¬" (depending on keyboard): (Repeated presses will select the next closest enemy). To select the enemy that someone in your party has already targeted, click on the party member’s name, then press the “F” key.
Kiting: To see an enemy as you are running away from him, mouse click in the far distance and then press the “Home” key. But if you just press the “Home” key while using Auto Run, you will run in the opposite direction!